Arch Dermatol. Dr Lestringant is a consultant dermatologist retired. In each case, the causative ABCA12 mutation was identified using standard polymerase chain reaction and sequencing techniques. Recurrent skin infections in infancy affected one-third of patients. With improved neonatal care and probably the early introduction of oral retinoids, the number of survivors is increasing. Compound heterozygotes appear to have a survival advantage.